I gave my dog simparica trio. I am both incredibly sad and angry. She spent 4 nights at the University of Auburn emergency room and vet clinic. I will use Sentinel and Pet Armor on her as this is what I have always gjven my dogs with no problems. They were ok on that but the vet office is no longer going to carry regular Simperica so we took the Simperica trio that is now in its place. What should I do? She will never have this again, I can assure you! He was given fluids, anti-nausea meds, meds to assist with the inflammation of his esophagus. Thanks Michelle! He already has canine dementia on and off. Other signs may include: Lethargy Loss of appetite This was days ago when I could still get food into him and the result. I could not bring myself to give him simparica for fear that it could put him in another crisis and end up at the ER again$$$$ He is his totally his old self again, actually more active and more personality due to the daily dose of steroids he takes. I say yes! Im wondering if there is any correlation as we havent changed anything else with him. The third ingredient in Simparica Trio is pyrantel. I have already had a bad experience with "k9 advantix", so I refuse to buy over the counter drugs for my 13 week old Auggie. Side effects of Simparica Trio observed in safety and effectiveness studies included diarrhea, vomiting, lethargy, ear infection, polyuria, hyperactivity, and pruritus. Hes very lethargic and constant vomiting! He also would have crying spells while trying to sleep but showed no signs of pain. They had no clue what had happened so again we took him to the er and he checked out fine. Discuss Simparica chewable treats with your veterinarian when looking for a safe, effective way to arm your dog against biting parasites and the diseases they carry. Hes not well..we hope he recovers fully! Follow up: my Labradoodle visited the ER on T-Day for 2 hrs. Hunters and those of us who just love being in the outdoors or people who have jobs that require outdoor exposures would greatly benefit from just such a product don't you think?, YET, there isn't one considered safe for humans. These products are approved for the treatment and prevention of flea infestations, and the treatment and control of tick infestations. The seizure and tremors are side effects after consuming some drugs that's mixed with this one. Contact your vet if your dog misses a month or more of heartworm preventionyour dog might have become infected with heartworm larvae. Sarolaner is an acaricide (kills ticks and mites) and insecticide (kills fleas) belonging to the isoxazoline class of drugs. No vet writer or qualified reviewer has received any compensation from the manufacturer of the medication as part of creating this article. A week and a half from taking the drug, he is still on 3 meds, taking fluids and starting to gain strength and eat food and drink water in very small amounts. Other alternative drugs are likely to offer poorer protection. I wish I would have came across this before I gave my healthy 9 month old puppy this medication two days ago. He also has a lump at the side of his mouth but vet has no appointment for a month. Also vets needs to tell the truth!!! Last month she had diarrhea and it lasted 7 days. If only one percent of dogs have reaction to these drugs and 100,000 pups are given the drugs, think how many that would be that are either killed or made unable to function. I gave him this medication last Thursday. My personal dog has had no issues at all, and she's been on it for nearly two years. Doubtful our dog will be given Simparica again. Thank you to all of you posting and I hope all of your babies are doing well. I gave my sweet little toy poodle Simpaica today, and one hour later this poor dog went from happy and healthy to having a terrible seizure. Got a new GS when the old one died. I am almost 100% sure that all of these symptoms are caused by this medication. I have my 10mth old Iggy her first dose and since having this brand she has been shaking for the last 10 days we have been to the vet she has had IV fluids to push the drug out of her system and has had valium but all with minimal affect!!! I have 3 other dogs - large breeds that also took 1 dose, but no reaction. And since then has had diarrhea and loose poop. Simparica is available by prescription only, so discuss any history your dog has of seizure disorders with your veterinarian when determining the best flea and tick treatment for your pet. They were good to deal with. Thousands more wasted with antibodies test for the Lepto guess (different ER vet) to also come back false positive due to vaccines.. my poor baby already had a rough life being abandoned. (On Monday, she fell down several times in an hour. I've had to syringe water in his mouth. I don't want another animal harmed by this stuff, one animal is one to many. When fleas or ticks bite the dog, they are exposed to the drug and killed during their blood meal. For Instance he has never liked grooming, I brushed him out last night and he slept through the whole thing. I lost my girl 2 days after taking Simparica. I have always used topical tx. Is it just me or does it seem like everyone is in this together? This seemed like perfect treatment 3 in 1 but at what cost? I have another dog, but gave him Frontline and he's fine. only 7 yrs old and I still considered a puppy b/c of how active he was, we are on 8 days now of the lethargic not eating, goopy eyes - Dr says he has hyernaited disc but I have yet to see the xrays to confirm - blood work came back normail. I understand them charging for the Euthanasia and cremation but they said they would keep her for 12 hours and she was put down at around 3:00 which was 1/2 the time they agreed on.Now he will get none of the fees back that the company offered for the dogs care, and hey don't have their dog .On top of that they have 3,500.00 vet bills.Why are vets allowed to charge so much?it is more than a person.It really seems as though they don't care about the pets or the people that own them Also why is these types of flea meds still on the market and why is there no legal action available for the poor consumers.I feel like they were legally assaulted by all involved and let us not forget the poor 2 year old rescue dog who ended up having a terrible short life.How unfair. (toy aussie & corgi). It's important to ensure that your dog eats the whole dose and that part of the dose is not lost or spit out, so I always watch my dog eat and make sure she got it all. The door is open , its where he prefers to sleep on a doggie bed . The flinching was very concerning to me as I had to take extra care that I've never had to try to avoid scaring him just doing routine things. Then things got progressively worse. Took her to her Vet where I was told she had another tremor. 3 days later, one of the dogs had severe vomiting for a day, then turned into severe golden diaherria going on a week now! Buddy 8 year old male Boxer formerly energetic and playful. Good bless you all. Today shes been panting. A heartworm test may be necessary in about six months (that's how long it takes heartworm larvae to mature enough to show up on a test). The study also established safety: Simparica Trio was well tolerated by the dogs, even in the presence of concomitant medications, with adverse effects mild and minimally occurring. You can do this by reporting to the drugs manufacturers, who are required to report this information to the FDA, or by submitting a report directly to the FDA. I shall be looking for a natural product from now on, k and g pet supplies on amazon do a good mange spray so hopefully that will be all they need from now on. If undiagnosed he would have died. Would appreciate any opinion you all may have. Sarolaner is also used in combination products for both dogs and cats. I will never give another dose to him! iI hope she will not have any other problems. Even when asked to go for a car ride he didn't respond. Same as you describe. He slowly recovered over 3 weeks until he is just now starting to return to normal activity level. Gave it to my dog on Thursday night and Sat stools were soft. If I still lived in the city, I would probably use the garlic because the previous GS never had any issues and lived a long time. I returned that medicine back to the vet and bought Revolution! I won't sleep until we all get the justice for our babies that don't have voices of their own. It's definitely not! She is more worried about excessive thirst, lip smacking and her kidneys. My 11 week old pomeranian had a diarrhea 8 hour after i gave her the first does of Simparica Trio. Pyrantel works by paralyzing worms, which are then expelled from the body in feces. And it looks like the liver and/or the kidney will not take it too. She hasnt eaten in 3 days and is unable to go up 2 simple steps. I found a warning from the FDA about the potential for neurologic adverse events in dogs and cats when treated with drugs that are in the isoxazoline class. we gave our dane Simperica Brown about a day or so ago and all the sudden my sweet girl is having seizures. Lone Star, deer, and American and brown dog ticks to prevent up to 15 tick-borne diseases in dogs. My last one lived to almost 15yrs old and I truly believe it was because I had him on Springtime Garlic tabs. Shame on you! I have been feeding her some white rice hoping it improves. Sorry to hear about this happening to so many. This dog was my partner and friend. I had to give him flea prevention because he goes to Daycare. But im 99% sure the simparica is what caused it. He did blood work and found that the phosphorus levels in her blood were way to low and that was causing the neurogical problems and it was most likely from Simparica Trio. Can someone please tell me if their dogs got better after taking the pill? Now I am terrified for his well being. . Vet said "cant be Simparica because he had 9 days ago". Now I have to pay $100's of dollars on meds to check her antibody and possibly put her on meds for life . Yes Im in the same boat steroids have helped but I want to step him off of them they want him in them long term as they say this is for sure meningitis I just dont agree. Simparica, NexGard, Bravecto & Credelio may not increase the number of seizures, but the risk is real. Not known if there be permanent after-effects. From classic to celeb-inspired and funny to food-based, this list of cute cat names is sure to inspire your naming adventures. We are beyond sad and livid! Our pups had been on next guard and heart guard with no issues but new vet stopped selling those products so switched to to the simparica trio - gave a dose to our 7 ur old 71 pound blue tick coonhound Frazier and our 10 mo 45 pound labradoodle- Watson. She became very neurotic, so many changes in her personality and she became very anxious her first and only dose was in November 2020 she never returned to the special dog that we had and she passed in March 2021 at 8 years old. The vet does not feel it is due to Simparica but i think it could be. It started working on him right away, Diarrhea. Best case scenario, he is able to come home, but we aren't there yet. On Friday he was incredibly thirsty - he would drink a full bowl of water and then look at me for more. Meaning he is suppose to get it today. And has been for about 3 weeks. 98. This may post twice - I didn't see my original post so I'm trying again! Gave our 23 month old Black Lab. Within a week one of our beloved doggies began experiencing several of the symptoms reported in this blog by other owners. I called my Vet and waited all day for them to call back, useless. It wasnt even four hours later all four of my dogs were throwing up, lethargic sick as hell didnt think they were gonna make it three pulled out my little Mr. weenie. He has been barking a lot more than he used to. If you think that your dog has had an overdose of Simparica, contact your vet immediately to seek treatment. I had placed an order with Pet Meds for the prescription before I saw any of these side effects.I will be returning this medication and order Heartgard and not sure what we will do for flea and ticks, since he turns his nos Simparica Trio, e to the Nexgard and we really dont feel safe with our Grandson around the topical or collarAny suggestions? Keep the medication in the blister packs provided until ready to use in order to protect from moisture and light. Strictly natural with zero side effects from now on. So you can imagine my worry now. Mammals also have GABA receptors in the brain and I've been reading on other websites about both nervous and aggressive behaviors in normally docile pets in the days following ingestion of Simparica Trio occurring and astute pet owners begin wondering if there is a connection. Now tremors started. HELP!! He drank not crazy about dog food . Thank u Fox I have good news I did get 2 additional in house potassium test done and they both came back normal. I have read that Simparica may cause side effects including muscle tremors, diarrhea, lethargy, anorexia, otitis externa, hyperactivity, neurological side effects, seizures, convulsions, anxiety and skin irritation . A week ago I gave him Trifexis because he had been on it a few years ago.the next night he had a seizure. He has been very lethargic, he was an extremely playful pup. And now that I'm reading all of these comments, a couple of hours ago, my puppy who I thought was sleeping, would be shaking and whining, (I'm used to him having bad dreams, and I'd wake him up from them). It seems to be clearing up with Rx eye drops. I am so sorry to all of you and my heart goes out to you and your babies. Coton de Tulear. I assume it's getting out of his system. Omg, this is beyond awful and makes me so worried. Please do NOT use it!! I had a trainer come in the day of, and he was with me the all day, NOTHING a happened for him to be in pain! Those with Diarrhea symptom, did it look like mucus in their pets stool? I hope it is better. She had terrible watery diarrhea and is not interested in eating. Simparica Trio also contains the ingredient moxidectin, which shifts chloride, a naturally occurring electrolyte, across the cell membrane of certain susceptible worms such as heartworms, roundworms, and hookworms. I would notice he gets super tired walking and would go limp in my arms. Hi there, So sorry to hear about your dog. Doctor prescribed the salyien with some injunction but all are in vain..my labrador has same issues till datemy vet.not says anything about the side effect of the Simparica..i m now helpless..pls help me what should I do.. please help me to rid over itpls pls ..guide me. Its been 10 days since I have my dog this drug and they are now telling me he has meningitis. At first B seemed fine. PROS Treats adult fleas and prevents flea and tick infestations Effective against five types of tick Liver flavored tablet FDA Approved CONS She would constantly twirl in left circles. He's experiencing auto-inmune disease symptoms and we were told he is in critical condition. The vet just gave our 16lb shorkie this on Tuesday and he still has the tremors really bad and very lethargic, Im very worried and concerned. Never again are my dogs getting oral medication for fleas & ticks. Drinking water and peeing excessively. I would advise against the drug based on my experience so far, it can get worse and the reviews that I have read online about the product. I will do anything to stop this from hurting or killing anyone else's baby. He is 5 months old. How can it not be the Simparica that did this to my baby when nothing else changed. Isoxazoline products have been associated with neurologic adverse reactions, including muscle tremors, ataxia, and seizures in some dogs and cats; Although most dogs and cats havent had neurologic adverse reactions, seizures may occur in animals without a prior history; Many products are available for prevention and control of flea and tick infestations. Simparica can cause ataxia, which is the official name for loss of body control. Then I saw this and realized. I just almost had a similar incident with my 16wk cavapoo. The FDA has approved this product for use in dogs between 5.6 and 11 pounds 1. I have written to the parent company that makes Simparico (although I don't hold high hopes that I will ever hear from them) and also signed an online petition at Change. Any believers out there please say a prayer for our pup as I will for the people on this thread. Again our dog had a major seizure in January and we searched for a neurologist ear by. 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